Know. Better. Updates.

NM: Heartburn and cancer: an interview with Mindy Mintz Mordecai

August 16, 2012

Remember to consumer low-acid diets and drink Evamor to help prevent heartburn from becoming more severe and dangerous than just being uncomfortable.


Please could you give us a brief introduction to heartburn, who it affects and how frequently it occurs?
What most of us think of as heartburn is a symptom of Reflux Disease or GERD (Gastroesophageal Reflux Disease). It’s that burning discomfort an individual experiences when stomach acids and other fluids come back up into their esophagus.

We use the phrase “Heartburn can cause Cancer” because heartburn is the symptom of Reflux Disease with which people are most familiar. Many also correctly connect Reflux Disease with a host of symptoms like nausea after eating, regurgitation, and a sour taste the mouth. But some people aren’t aware that GERD can also cause a chronic cough, hoarse voice or sore throat, chest pain, even a choking sensation upon lying down.

Reflux Disease can affect just about anybody and it is very common. In the United States, it’s estimated that 25 million adults will suffer from Heartburn each day and 40 percent of the entire adult population will experience it at least once each month.

What causes heartburn?
What causes the burning sensation of Heartburn is the irritation caused by the splashing of fluids from the stomach back up into the esophagus. Those fluids also cause the irritation that produces the other symptoms of Reflux Disease.

What types of cancer can heartburn cause?
Persistent Heartburn and Reflux Disease can cause Esophageal Cancer, a particularly deadly type of cancer that will kill four out five patients diagnosed with the disease. The poor survival rate is due in large part to the fact that the Esophageal Cancer is usually detected in late stages, when it is very hard to treat.

There are two types of Esophageal Cancer. The type caused by Heartburn and Reflux Disease is Esophageal Adenocarcinoma. This type of Esophageal Cancer is most prevalent in the United States and it’s increasing rapidly throughout the Western World.

The other type of Esophageal Cancer, squamous cell carcinoma, is more often associated with smoking and drinking and was once the most prevalent type of Esophageal Cancer in the U.S. But, in recent years, squamous cell carcinoma has declined dramatically in the US and the Western World, but the bad news is that Adenocarcinoma has increased just as rapidly as the other type has declined. Squamous cell carcinoma remains the most prevalent type of Esophageal Cancer in the world and it is one of the top cancer killers in many Asian nations.

By what mechanism does heartburn cause cancer?
The esophageal lining can respond with cellular change to the irritation caused by the fluids brought back up when someone experiences Reflux Disease. The lining of the esophagus can react in response to the caustic fluids from the stomach by becoming more like the lining of the stomach. When this occurs, patients have a condition called Barrett’s Esophagus. Barrett’s Esophagus can become dysplastic – pre-cancerous – and, if this condition is not treated, it can become malignant.

New, outpatient procedures are now available to treat Barrett’s Esophagus. Some of those methods of addressing the condition have produced impressive results – curing the condition in 97 percent of cases and potentially eliminating the risk of developing Esophageal Cancer.

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